What happens if I leave my lupus untreated?

Lupus Foundation of America

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Because lupus is such a complex and variable disease, it is difficult to predict or generalize about what would happen if it were left untreated.

The severity of lupus should guide treatment decisions

People with lupus should have regular evaluations to make sure life-threatening organ involvement is not developing. For individuals with severe organ involvement—such as kidney inflammation—consistent medical treatment is very important.

Because treatment decisions are guided by the degree and severity of disease manifestations, it is important for a person with lupus to be aware of their symptoms. Up to 50% of lupus patients may have non-life threatening symptoms such as fatigue, joint pain, and rash. Non-steroidal anti-inflammatories (e.g. ibuprofen) and antimalarials (Plaquenil) are frequently used for symptomatic relief in this case.

Even in cases of mild disease, regular monitoring is critical

Due to the risk of disease flares with more severe organ involvement (kidney or lung/heart inflammation, for example), lupus patients should have regular evaluations to make sure life-threatening involvement is not developing. Many lupus doctors prescribe antimalarials even in the setting of mild disease because there is good evidence they may decrease the frequency and severity of flares and have low toxicity.

Treatment improves long-term survival 

95% of those in treatment are still alive after 5 years.

Before medications (like steroids and other immunosuppressants) were available to treat lupus, overall five-year survival rates were less than 50%. With expanded therapeutic options, 5 year survival rates are now over 95%.